Class of intervention

Methods

Advantages

Disadvantages

Reference

Physical or Environmental Control Measures

* Reduction of human/mosquito contact based on community participation following educational efforts

Encourage community to participate in the planning of surveillance, evaluation, and management programmes, reducing sources of standing water

[44]

* breeding site removal (Source Reduction)

Reducing  aquatic habitats for larval development

The vast number of breeding sites making the task difficult to achieve

[20]

* Sampling and collection

Selection of appropriate sampling methods depends on the surveillance objecives

It takes time, extensive  effort required

[20]

Chemical Treatment

* Insecticides

The most important component in the vector-control effort

Development of resistance to pyrethroids, prohibitively expensive, unsustainable, and environmentally undesirable, toxic for public health

[145] [146]

Biological Control

* Establishment of Wolbachia in mosquito populations

Powerful mechanism to invade natural populations through cytoplasmic incompatibility

Uninfected females are therefore at a disadvantage, fitness disadvantage

[66]

*Recombinant bacteria

Alternative of insecticides use

Reduced effectiveness, expense of raising the organisms, difficulty in their application

[63] [147]

Genetic Control Strategies

* Sterile Insect Technique (SIT)

Temporary persistence in the environment

Strain instability, negative effects of sterilization by irradiation, difficulties in sex-separation procedures, the cost of the control program

[148]

≠ Release of Insects with a Dominant Lethal (RIDL)

Short-lived presence of the genetically modified organism in the population, focus on the release of males that will not increase nuisance biting, temporary persistence in the environment

More expensive than chemical methods, political resistance to releasing large numbers of transgenic mosquitoes, in  development

[65] [149]

* RNA interference

Improving the natural defense system of the mosquito

The effectiveness of the transgene is diminished by genetic changes occur­ring outside the targeted region, Stability and loss of a virus resistance phenotype over time, in development

[65] [150] [151]

≠ Homing Endonuclease Genes (HEG)

Viability or fecundity, that are active in one sex or both

Genes may not be expressed in the correct tissue, without long-term persistencein development

[149]