Class of intervention | Methods | Advantages | Disadvantages | Reference |
Physical or Environmental Control Measures | * Reduction of human/mosquito contact based on community participation following educational efforts | Encourage community to participate in the planning of surveillance, evaluation, and management programmes, reducing sources of standing water | ||
* breeding site removal (Source Reduction) | Reducing aquatic habitats for larval development | The vast number of breeding sites making the task difficult to achieve | ||
* Sampling and collection | Selection of appropriate sampling methods depends on the surveillance objecives | It takes time, extensive effort required | ||
Chemical Treatment | * Insecticides | The most important component in the vector-control effort | Development of resistance to pyrethroids, prohibitively expensive, unsustainable, and environmentally undesirable, toxic for public health | |
Biological Control | * Establishment of Wolbachia in mosquito populations | Powerful mechanism to invade natural populations through cytoplasmic incompatibility | Uninfected females are therefore at a disadvantage, fitness disadvantage | |
*Recombinant bacteria | Alternative of insecticides use | Reduced effectiveness, expense of raising the organisms, difficulty in their application | ||
Genetic Control Strategies | * Sterile Insect Technique (SIT) | Temporary persistence in the environment | Strain instability, negative effects of sterilization by irradiation, difficulties in sex-separation procedures, the cost of the control program | |
≠ Release of Insects with a Dominant Lethal (RIDL) | Short-lived presence of the genetically modified organism in the population, focus on the release of males that will not increase nuisance biting, temporary persistence in the environment | More expensive than chemical methods, political resistance to releasing large numbers of transgenic mosquitoes, in development | ||
* RNA interference | Improving the natural defense system of the mosquito | The effectiveness of the transgene is diminished by genetic changes occurring outside the targeted region, Stability and loss of a virus resistance phenotype over time, in development | ||
≠ Homing Endonuclease Genes (HEG) | Viability or fecundity, that are active in one sex or both | Genes may not be expressed in the correct tissue, without long-term persistencein development |